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An animal study showed that AST supplementation for 45 days (1 mg/kg bodyweight) increased muscle antioxidant status, controlled oxidative stress and delayed exhaustion [50]

This decrease in cell survival strongly suggests the occurrence of ferroptosis in response to erastin treatment (125)

In Long COVID, oxidative stress may be driven by: persistent immune activation mitochondrial dysfunction mast cell activation (MCAS) chronic inflammation autonomic nervous system dysregulation psychological stress (PTSD, illness trauma) Even everyday factors can worsen the burden: travel overexertion poor sleep emotional stress Supporting the Body Against Oxidative Stress While research is ongoing, strategies that may help reduce oxidative stress include: Foundational Support Anti-inflammatory nutrition Adequate hydration Sleep optimization Stress reduction Nervous System Regulation Breathwork Pacing strategies Reducing overstimulation Nutritional & Clinical Considerations Antioxidant support (as clinically appropriate) Mitochondrial support Addressing histamine and MCAS if present Always consult with a qualified provider before starting new treatments or supplements

Improves insulin response:Insulin resistance also develops type 2 disease