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Mechanisms of PLGA-based nanoparticles transport across the BBB The transport of PLGA-based nanoparticles across the BBB is mediated by active or passive transporters 118

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In murine models, cyclosporine, functioning as a CypA inhibitor, diminishes the CypA-NF-B-MMP-9 pathway associated with BBB degradation and neurodegenerative changes