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Studies have shown that a single dose of L-citrulline does not improve the ability of the arteries to widen in either healthy or diseased individuals ( However, when people who have heart disease or are at risk of heart disease have consumed L-citrulline for seven days or longer, the ability of their arteries to widen has improved ( So, although a single dose may not be very effective at widening your blood vessels, taking supplements in the longer term may be more effective

[DOI] [PubMed] [Google Scholar] Kasai K

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Although not reversed, the ageing effect was mitigated by NOx treatment, especially after 14 and 21 days of ageing