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Plus, while our bodies can produce some antioxidant compounds, production of those antioxidants naturally declines with age

HeLa cells were treated with a series of concentrations of buthionine sulfoximine (BSO) for 72 h, a specific inhibitor for the enzyme required in the first step of GSH synthesis (Fig

ROS, lipid peroxides and MDA levels were lower in cisplatin resistant osteosarcoma cells, which may be related to the increase of antioxidant enzymes such as GPX4

This is possibly due in part to the loss of the negative feedback circuit from mTORC1 to the PI3K/AKT/mTORC2 signaling axis, which mediates cell survival