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The aim of surgery for IVD disease is to relieve the compression of neural structures, and procedures include removal of the NP (nucleotomy) through fenestration of the AF alone or combined with partial removal of the vertebral roof (laminectomy) or vertebral body (ventral decompression) [12]

Additionally, atrophic gastritis, common in elderly populations, can reduce intrinsic factor production

MARCH was a 26-week, randomized, placebo-controlled (PBO), Phase 3 trial of maralixibat (MRX), an ileal bile acid transporter (IBAT) inhibitor, that achieved its primary and key secondary endpoints of pruritus and sBA reduction for individuals across the broadest range of PFIC types studied

Rotenone is assumed to exert its cytotoxicity in part through the induction of apoptosis