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Anodal ctDCS may facilitate cerebellar excitability by enhancing the inhibitory activity of Purkinje cells onto the deep cerebellar nuclei, thereby exerting less facilitatory drive to contralateral thalamic nuclei and the cerebral cortex [195]

The honest accounting of the evidence: while these mechanisms are compelling and the animal data is genuinely encouraging, the absence of human randomized controlled trials for all three compounds means that anyone using them for serious GI conditions should do so as a complement to evidence-based medical care not as a replacement for it