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Strikingly, the synthesized Ru-hydroxide exhibits efficient in vivo biocatalytic microenvironment modulation during inflammatory bone tissue regeneration, providing a hopeful avenue for developing antioxidase-like biomaterials to treat a broad range of inflammation-associated diseases, such as arthritis, diabetic wounds, enteritis, and bone fractures

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Plasma TMAO levels are directly modulated by dietary choline/red meat intake (179, 180)necessitate extremely careful therapeutic window definition and sophisticated tumor-targeted delivery strategies (e.g., PERK-activating nanoparticles) to avoid unacceptable systemic toxicity