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Although the leading cause of migraine is not clear, inflammation has been considered as one of the important risk factors

The integration of spatial proteomics technologies, including imaging mass spectrometry and multiplexed immunofluorescence, complements spatial transcriptomics by providing protein-level information with spatial context [45, 46]

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30 The altered NP cell phenotype can maintain the catabolic environment during disc degeneration 31 and has shown to be responsible for the drop in local pH mediated by, among others, acidsensing ion channels (ASICs) 32 that in turn causes IVD cell loss and ECM breakdown