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The patients medical record should include: - The diagnosis or condition requiring contrast-enhanced MRI (e.g., brain tumor, multiple sclerosis, vascular malformation)

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This is a deliberate feature of how each protocol page is built, not an inconsistency the 20 mg vials more concentrated fill is documented at a smaller per-dose so a single vial stretches across a longer research window

However, it is not known whether vitamin B 12 supplementation, in addition to folic acid supplementation, may be beneficial in the prevention of NTD (62) randomized controlled trials are needed to address this question