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Thus, our results confirm the beneficial effect of FGF21, which not only protects from obesity, insulin resistance, and dyslipidemia but also prevents NAFLD, as shown in DIO mice with FGF21 deficiency in hepatocytes, where the Mat1a ASO treatment increased liver TG to higher levels than in the ASO-treated DIO control mice

We are continually exploring new models for assessing binding site abilities, with lysine poised to become the next research hotspot among targeted amino acids due to its numerous protein binding sites and extracellular locations

While continued research is needed to understand the biological pathways of acetaminophen, the current evidence does not support causation

Trends Mol Med (2021) 27(10):9314