Cluster 3 includes PTGS1, PTGS2 , and ALOX5 involved in prostaglandin metabolism and leukotriene receptor activity, whereas Cluster 4 ( MMP9, MMP2, ITGB8, LOX, TIMP2, and VCAM1 ) and Cluster 5 ( MMP9, MMP2, LOX, TIMP2 ) were found to trigger extracellular matrix organization, elastic fiber formation, and matrix metalloproteinases activity
Nthunya LN, Mosai AK, Lpez-Maldonado EA et al (2025) Unseen threats in aquatic and terrestrial ecosystems: nanoparticle persistence, transport and toxicity in natural environments
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Abbreviations GSH: Glutathione TTH: Tension-type headache HC: Healthy control MRS: Magnetic resonance spectroscopy MEGA-PRESS: Mescher-Garwood Point Resolved Spectroscopy ROC: Receiver operating characteristic AUC: Area under the curve MIDAS: Migraine Disability Assessment HIT-6: Headache Impact Test-6 CRLB: Cramr-Rao lower bounds FWHM: Full width at half maximum Glu: Glutamate mI: Myo-inositol tCho: Total choline NAA: N-acetylaspartate tNAA: Total NAA ROS: Reactive oxygen species NAC: N-acetylcysteine References Steiner TJ, Stovner LJ, Jensen R, Uluduz D, Katsarava Z (2020) Migraine remains second among the worlds causes of disability, and first among young women: findings from GBD2019
