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Andrew Hub...: So, time in every 24 hour cycle when [00:30:00] your body temperature is lowest, and rather than go actually measure that with a device, which would be wonderful to do, but I'm guessing most people aren't equipped with that kind of technology, you can ask yourself, "Well, when would I naturally get up without an alarm and have an interrupted night of sleep?" And temperature minimum is typically about two hours before that time

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Treatment effect estimation For each tested drug, we estimated drug treatment effect for each balanced trial by calculating the hazard ratio (HR) using a Cox proportional hazard model 102 , comparing the risk to develop a specific outcome between the treated and control groups

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