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Therefore, an increased supply of Met may increase antioxidant production, potentially aiding in the relief of oxidative stress and inflammation triggered by the production of reactive oxygen metabolites ( Conversely, Hcy has the capacity for remethylation to regenerate methionine, which relies on the folate cycle and vitamin B 12 ( Figure 1 ) ( 2 -THF), which is subsequently reduced to 5-methyltetrahydrofolate (5-CH 3 -THF) (Preynat et al., 2009)

For B12 to be absorbed, it requires a protein called intrinsic factor (IF)

Identification of nicotinamide Nmethyltransferase as a promising therapeutic target against diabetic cardiomyopathy

Time Frames: From baseline (week 0) to end of treatment (week 64)