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In rodent work, subcutaneous administration is the route most commonly used for both compounds in published mechanistic studies

Daratumumab is approved as monotherapy and in combination with IMiD drugs (i.e., lenalidomide or pomalidomide based on the POLLUX, EQUULEUS, and APOLLO trials) or PIs (i.e., bortezomib or carfilzomib based on the CASTOR and CANDOR trials), plus dexamethasone for RRMM patients

In addition, inhibition of UCPs with guanosine diphosphate also normalized mitochondrial uncoupling, indicative of ROS-induced uncoupling

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