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What they found (summary): Amylin is a critical partner of insulin in metabolism, the loss of amylin in T2DM is as significant as the loss of insulin The AMY1 receptor in the area postrema is the primary target for the appetite effect Amyloid aggregation is the main problem with native amylin, proline substitutions (the Pramlintide strategy) are essential The half-life of native amylin is only 13 minutes, that is why lipidated analogs like Cagrilintide are necessary Perspective: amylin + GLP-1 combinations are the natural evolution of metabolic pharmacotherapy Why it matters: This is the reference article for amylin pharmacology

Christmas TJ, Holmes SA and Hendry WF: Bladder replacement by ileocystoplasty: The final treatment for interstitial cystitis

That tissue is doing its best with a supply line that runs on fumes

While RS largely refers to an individual's overall satisfaction with his or her living environment, many studies fail to clearly distinguish NS as a subcomponent of RS, leading to conceptual and methodological inconsistencies