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The number of NPPCs declines precipitously with aging and degeneration [36, 60], and those that remain must contend with a hostile microenvironment defined by acidity, profound hypoxia, inflammatory mediators, and aberrant mechanical loading

Free Radical Biol Med 65:468476

FIGURE 3 3.3.2 Insulin-like growth factor I-related proliferation and apoptosis Higher serum level of insulin-like growth factor I (IGF-I) has been associated with an increased risk of cancer by stimulating proliferation and suppressing apoptosis (Vrieling et al., 2007) (Figure 3)

This combination of actions is associated with meaningful reductions in body weight, primarily through appetite suppression and slowing of gastric emptying