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However, high levels of IGFBP-3 in breast tumor tissues are associated with increased xenograft growth in mice and poor prognosis

It is very likely, therefore, that HIF-1's oxygen responsiveness resides over a permissive range of antioxidant buffering capacities, with the demonstration that the antioxidant/pro-oxidant equilibrium effectively uncouples HIF-1 activity from the normal pattern observed in response to variations in p O 2 in the alveolar epithelium [13, 14, 82]

From a clinical perspective, this increased diversity complicates the identification of therapeutic strategies to eradicate cancer cells

This rate is much higher in the Northern Plains and much lower in the East, where the nongender related rates demonstrate the same overall trend