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Weakness and fatigue are common symptoms of vitamin B12 deficiency

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The ability of benfotiamine to inhibit three major pathways (the hexosamine pathway, the AGE formation pathway, and the diacylglycerol (DAG)-PKC pathway) simultaneously might be clinically useful in preventing the development and progression of diabetic complications

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Intramuscular These injections typically have better results and inject the medicine directly into the muscle, which is then absorbed by the surrounding muscle immediately

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However, the exact cut-offs to classify clinical and subclinical deficiency remain debated

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