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The insight that changed this view is that when glucagon receptor activation occurs alongside GLP-1 activity, the net effect is a shift toward increased energy expenditure and fat oxidation rather than hyperglycemia

When present, side effects are typically mild and transient, potentially including slight drowsiness if administered too early (easily resolved by timing adjustment), mild headaches during initial adaptation in some individuals (usually resolving within days), temporary vivid dreams as sleep architecture normalizes, or rare reports of mild dizziness upon waking in sensitive individuals

In this case, the UPR can activate apoptotic signalling pathways that lead to cell death [45, 46]