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The renoprotective effects of berberine are largely attributed to its ability to mitigate oxidative stress, suppress inflammatory pathways, and inhibit apoptotic processes, as evidenced by the reviewed literature (Table 1)

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In addition, curcumin treatment of isolated PSCs suppressed the expression of TGF--induced fibrosis-associated genes via the Nrf2/HO-1 pathway

(PubMed) Robins RS, Lemarie CA, Laurance S, Aghourian MN, Wu J, Blostein MD