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The difference is that leucovorin has been altered in a way that makes it easier to get through the blood-brain barrier for people who cant metabolize folic acid, he says

Traditional immunosuppressants work like a volume knob turned all the way down

If you are vegan, poorly digesting or absorbing foods such as having chronic gastritis, Crohns disease, or ulcerative gastritis, or if you have an autoimmune disorder such as Graves disease or lupus you can be deficient in vitamin B12