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Understanding why glycine does what it does requires a brief tour of its biochemistry: where it sits in the metabolic network, which receptors it binds, and how its apparent deficiency connects to the hallmarks of aging

Activating transcription factors (ATFs) have recently been recognized to modulate multiple signaling pathways, including the MAPK cascades, endoplasmic reticulum stress response and NFB signaling, thereby regulating macrophage biological processes such as inflammatory response, glucoselipid metabolism, cellular stress adaptation, autophagyapoptosis balance and senescence

57 , e13712 (2024)

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