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It's a reflection of transformation - internal and external

There is an emerging consensus that situations of acute or chronic imbalance between the antioxidative capacity of cells and tissues, and the production of pro oxidative species, is associated with the development of a number of human diseases

Levels of free radical species in healthy tissues exert important intracellular signal transduction and regulatory functions in folliculogenesis, maturation of oocytes, dissolution of corpora luteal, implantation, and embryo development ( Reactive oxygen species in vivo The predominant ROS species are O, hydrogen peroxide (H 2 O 2 ), and, hydroxyl radical ( OH) ( Superoxide anion Approximately, 15% of molecular oxygen is converted into O by mitochondrial complexes during normal respiration ( is a highly reactive radical that does significant intracellular damage

The canonical pathways most activated in CKD5 included: EIF2 Signaling, NRF2-mediated Oxidative Stress Response, and Glutathione Redox Reactions