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RYGB substantially improves or even remits several cardio-metabolic comorbidities associated with obesity such as type 2 diabetes mellitus (T2D), dyslipidemia and hypertension, decreasing cardiovascular mortality 15 and increasing life expectancy compared to non-surgical obesity management 21

doi: 10.1101/gad.346105 67

Reduced reticulum-mitochondria Ca2+ transfer is an early and reversible trigger of mitochondrial dysfunctions in diabetic cardiomyopathy

Keywords: macronutrients, micronutrients, inflammation, vaso-occlusive crisis (VOC) Introduction Sickle cell disease (SCD), involves widespread single-gene disorder hemoglobinopathies