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Jenabi M, Khodarahmi P, Tafvizi F, Bostanabad SZ

The complexes ability to simultaneously target ROS-sensitive proteasomes, topoisomerases, and copper-dependent mitochondrial pathways creates a polypharmacological profile that disrupts multiple cancer hallmarks

Finally, we provide an overview of preclinical and clinical evidence for microbiome-targeted therapies (probiotics, prebiotics, fecal microbiota transplantation) in alleviating DGE symptoms and repairing ENS while outlining translational challenges and future research priorities