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They start secreting anti-inflammatory cytokines including TGF-1, which promotes ECM production and wound contraction, during this phase

NF-B can be activated by two major canonical and noncanonical pathways

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Patients were randomized (2:1) to one of the following treatment arms: Pemetrexed for injection 500 mg/m2, pembrolizumab 200 mg, and investigators choice of cisplatin 75 mg/m2 or carboplatin AUC 5 mg/mL/min intravenously on Day 1 of each 21-day cycle for 4 cycles followed by pemetrexed for injection 500 mg/m2 and pembrolizumab 200 mg intravenously every 3 weeks