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This surrogacy is especially robust for rare, monogenic variants with large effect sizes, which are more likely to exhibit Mendelian patterns of inheritance within families than common variants with individually small effect sizes

Vitamin B12 deficiency symptoms Weakness, tiredness, or lightheadedness Heart palpitations and shortness of breath Pale skin A painful, smooth, inflamed tongue (glossitis) Digestive issues Bluish or gray-brown nails Loss of appetite What happens if your vitamin B12 deficiency is left untreated

Incorporating supplements into your daily routine based on the needs of the body can help