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Stress, Cortisol, and Oxidative Burden Chronic psychological stress elevates cortisol and other stress hormones, which increase oxidative stress through multiple mechanisms including promotion of inflammatory cytokine production, impairment of antioxidant enzyme function, increased metabolic rate and oxygen consumption, and disruption of sleep and other restorative processes

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Figure 16 shows key design considerations for redox-responsive drug delivery systems

Oxidative stress index in lung tissue A portion of the tissue preparation was made from right lung tissue that was homogenized with normal saline, and the preparation was centrifuged at 2500 rpm at 4 C for 10 min