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MOR are also present in the superficial layers of the dorsal horn of the spinal cord (Besse et al., The distribution of KOR demonstrates some of the most striking species differences among the OR types

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This is most likely attributed to the inability of the constrained 13- and 14-membered macrocycles to adopt the proper transition states required for cleavage of the N-terminal peptide bond (Andersson et al., 2011) (Figure 8)

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