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Exposure of murine J774A.1 cells to the weakly estrogenic plasticizer, bisphenol S (BPS), increased levels of glycolytic metabolites (e.g., lactate, pyruvate, and glucose-6-phosphate) and increased mRNA and protein expression of glycolytic enzymes (e.g., PKM2, LDHA, hexokinase 1 [HK1], and HK2)

Comparing germ-free mice to conventionally grown (CONV-R) mice, it has been shown that the former had increased bone mass due to their changed immunological state, which includes lower pro-inflammatory cytokines, decreased CD4+ T cells, and fewer osteoclasts/precursors in the bone marrow (220)