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[3] For thymosin beta-4 / TB-500 , the parent protein has been studied in cardiac and neural injury models and in corneal and dermal repair, with reported effects on cell survival, inflammation, and progenitor-cell mobilization

Peroxiredoxin 4 protects against nonalcoholic steatohepatitis and type 2 diabetes in a nongenetic mouse model

While these inconsistent results may be partly influenced by bias associated with relatively small sample sizes, a more critical factor is the substantial heterogeneity of PDAC, as baseline autophagy activity likely varies across tumors