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Description

They become more pronounced with age as the face loses collagen and fat, the skin loses elasticity, and the cheeks descend slightly deepening the fold

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The most common pathogenic mutation in LRRK2, G2019S, exhibits slowed degradation and can inhibit CMA by disrupting the formation of translocation complexes at the lysosomal membrane, leading to impaired degradation of LRRK2 within lysosomes (167)