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These pharmacological effects are mostly exerted by a single active substance extracted from coral bodies, while the bones of corals are mostly used as materials for bone transplantation and other applications (Wang et al., 2002b)

However, this variant is rare, and one should hesitate to make this diagnosis in an adult person unless the summary of findings (small size, sharp circumscription, good maturation of the dermal component) favors a nevus and the pagetoid spread shows some uniformity (usually limited to the lower part of the spinous cell layer, not asymmetrically localized to the edge of the lesion)

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These peptide groups can vary in solubility depending on batch format, concentration, storage history, solution volume, and handling conditions