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67 Rapamycin was initially approved by the FDA in 1999 as an immunosuppressant for treating posttransplantation autoimmunity, which specifically suppresses the activity of mTORC1 in mTOR signaling and eventually disrupts cell proliferation and cell cycle progression of T cells while promoting immunosuppressive Treg development from nave T cells

Superoxide radical scavenging by ascorbate is approximately 100 times more effective than that by glutathione (rate constants 3 10 5 M 1 s 1 vs 1 10 3 M 1 s 1 ) (Zhitkovich 2020)