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The 1993 New England Journal of Medicine study on tretinoin showed an 80% increase in Type I collagen formation in photodamaged skin after 10 to 12 months of treatment

Nat Rev Mol Cell Biol 2015;16, 393405, doi: Baar, M

KPV also reduces the expression of swelling enzymes including cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), which produce swelling mediators prostaglandins and nitric oxide respectively

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