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revealed the correlation between microorganisms and tumor metastasis through clinical evidence, showing that the abundance of Fn in colorectal cancer is significantly positively correlated with the risk of liver metastasis (Rubinstein et al., 2013)

& Davison, G

In REDEFINE 1, adverse events were mainly gastrointestinal (79.6% in the CagriSema group vs 39.9% with placebo) including nausea (55% vs 12.6%), constipation (30.7% vs 11.6%), and vomiting (26.1% vs 4.1%)