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Description

Adam, B., Liebregts, T., Saadat-Gilani, K., Vinson, B

Lab Invest

Cuando clulas son expuestas a estrs oxidativo o a electrfilos, oxidacin de residuos de cistena en Keap1 causa cambio conformacional que libera Nrf2 permitiendo su translocacin nuclear y activacin de genes diana incluyendo glutatin S-transferasas, NAD(P)H:quinona oxidorreductasa, hemo oxigenasa-1, y subunidad cataltica de glutamato-cistena ligasa que sintetiza glutatin