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This study also found that anti-doxorubicin produced inflammation and oxidative stress in the kidneys, and that doxorubicin plus apigenin increased resistance to doxorubicin in breast cancer cells via the JAK/STAT signalling pathway (162)

both processes jointly compromise plaque integrity ( 2.5.2 Pyroptosis Pyroptosis is a highly pro-inflammatory form of programmed cell death mediated by the gasdermin D protein ( 2.5.3 Ferroptosis Ferroptosis is an iron-dependent regulatory cell death process driven by lipid peroxide accumulation, characterized by glutathione depletion and loss of glutathione peroxidase 4 activity ( In summary, apoptosis, pyroptosis, and ferroptosis play pivotal roles in the initiation and development of atherosclerosis through their distinct molecular pathways

F.Illek (2021)