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Zhong X, Wang Y, He X, He X, Hu Z, Huang H, et al

The elevation of ROS levels and dysregulation of redox homeostasis affect numerous intracellular processes and machineries such as gene expression, energy metabolism, molecular signaling, and epigenetic modifications 22

Phosphorylated IRF3 undergoes dimerization and translocates to the nucleus, initiating the expression of IFN-I

It was measured in human clinical trials using corneal confocal microscopy, a technique that directly visualizes and quantifies small nerve fiber density