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Different studies supported that TGF-1 suppresses gene expression of glutamate cysteine ligases (GCL), an enzyme implicated in the biosynthesis of GSH, in alveolar epithelial cells (Jardine et al., 2002)

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In decreasing order, the most frequent neoplasms in NF1 are optic nerve glioma (ONG) (15%-20%), malignant peripheral nerve sheath tumor (MPNST) (8%-13%), gastrointestinal stromal tumors (4%-25%), and pheochromocytomas (0.1%-5%).35 In addition, patients with NF1 are at 7 to 5 times greater risk than the general population of developing leukemia, brain tumors, and breast cancer