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While our findings of neurochemical abnormalities in the pgACC and dACC, in ME/CFS and long COVID patients are intriguing, they must be viewed with caution given the limitations of the study

However, the root cause approach also emphasizes getting the right kind of protein to fulfill our amino acid needs, optimizing low stomach acid levels, as well as addressing nutrient deficiencies and issues related to MTHFR gene variations

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The authors gratefully acknowledge the support of the patients and medical staff of Golestan Hospital who volunteered to contribute to this study