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Additionally, TNF- stimulated the expression of K16 and K17, whereas SFN suppressed their expression (Fig

Although we failed to obtain the crystal structure of cFSP1 in complex with NAD(P)H, the high conservation of the NADH binding mode in NADH:quinone oxidoreductases readily allowed the bound NADH observed in Caldalkalibacillus thermarum NDH-2 to be modeled into cFSP1 in NAD(P)H-binding pocket of NBD, with the nicotinamide ring approaching the re-face of the FAD and a conformation change of Tyr343 of the other chain in cFSP1 dimer in order to avoid a steric clash (Supplementary Fig

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