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Ismail Kimji, MD, FRCPC, fellow of the Royal College of Physicians and Surgeons of Canada, reviewed the clinical statements, safety protocols, contraindication lists, and protocol guidance

Indeed, glycine supplementation has been reported to slow the growth of various implanted tumors in rodents, likely owing to an antiangiogenic impact on endothelial cells.72-74 However, this effect might modestly retard wound healing.73 The antiangiogenic effect of glycine may reflect the fact that activation of endothelial NADPH oxidase, which the hyperpolarizing action of glycine may oppose, is a key mediator of the signaling pathway whereby vascular endothelial growth factor and its Flk-1 receptor promote proliferation and migration of endothelial cells.75,76 Additionally, glycine acts directly on a human hepatocyte line, via glycine receptors, to inhibit expression of vascular endothelial growth factor

Khan AA, Allemailem KS, Almatroodi SA, Almatroudi A, Rahmani AH

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