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From k activation , the intracellular H 2 O 2 concentration attained during the experiment was calculated using the published value k target + H2O2 = 1.4 10 5 M 1 s 1 for OxyR and therefore, by inputting the known experimental extracellular H 2 O 2 concentration, the gradient between the extracellular and the intracellular concentrations of H 2 O 2 was estimated

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Glutathione (GSH) is an important antioxidant that neutralises harmful free radical and reactive oxygen species (ROS) substances and prevents against oxidative stress