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This phase 2 trial evaluated the BTK inhibitor evobrutinib compared to placebo and showed high doses of evobrutinib can significantly reduce the number of central nervous system lesions identified on MRI in MS patients, though clinical markers of disease progression were not altered with evobrutinib treatment at 24 weeks

This guide is for educational purposes only

58 In response, in October 2011 each Service and OSD published Broad Agency Announcements (BAAs) 59 inviting RIF applications by November submission deadlines and describing the RIF execution and program purpose as in this example from Navy: The goals of the Navy Rapid Innovation Fund (RIF) are to enhance and accelerate delivery of military capability, reduce the cost of weapons systems either fielded or under development, or improve the quality of life for service personnel, by meeting urgent operational needs or other critical national security needs. 60 The new RIF funding attracted a large number of applications, resulting in success rates lower than those for standard Phase I SBIR awards