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Description

The somatic mutation of oncogenic KRAS is the most recognized genetic alteration and is thus the most attractive drug target in PDAC [15, 16]

Signatures of mutation and selection in the cancer genome

The translation pipeline (Figure 3) typically progresses from identifying a promising metabolite or herbal formula, demonstrating efficacy in cellular and animal models, ensuring quality control in formulation, conducting early-phase human safety studies, then larger efficacy trials, and finally seeking guideline inclusion if successful