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In line with the findings in humans, IGFBP-2 serum concentrations were markedly increased in nephrotic animals despite excessive urinary losses due to increased hepatic synthesis, whereas hepatic synthesis of IGFBP-3 was unchanged compared to controls

For accumulation of a drug it is useful to predict that 50% accumulation is reached after one half-life and 75% after 2 half-lives

Detailed information of docetaxel administration Values are presented as median (range) or number (%)