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Coexpression of perilipin A and HSL in CHO cells results in a cooperative effect that produces a more rapidly accelerated lipolysis following PKA stimulation than is evident in cells that express either protein alone (125)

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In phase 3 trials, semaglutide and tirzepatide achieved between 14.9% and 20.9% reduction in body weight after one year, as well as improvement on cardiovascular risk factors (Jastreboff et al., 2022