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Necrotizing mediastinitis: Decreasing mortality through an algorithmic approach

As OxS plays an important role in PSC activation and pancreatic fibrosis, we hypothesized that high glucose could stimulate pancreatic cells to produce excess ROS and activate PSCs, that induce pancreatic fibrosis and ultimately lead to -cell failure

The multifaceted nature of PD comorbidities necessitates a precision medicine approach tailored to the patients full clinical context (Panicker et al., 2021