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In particular, the Nf-B complex and the upstream proteins, as TRAF6, are negatively regulated by glutathione ( Glutathione plasmic levels and GP activity in patients with psoriasis were significantly lower than in general population ( Glutathione intracellular depletion in human antigen-presenting cells causes IL-10 production, with immuno-modulatory action, instead of the pro-inflammatory cytokines IL-12 and IL-23, responsible for Th1/Th17 immune system response switch in psoriasis

The article will explain glutathione, its functions, sources, formulations, possible side effects, and future research for further therapeutic use

Yzydorczyk C, Li N, Rigal E, Chehade H, Mosig D, Armengaud JB, Rolle T, Krishnasamy A, Orozco E, Siddeek B, Juvet C, Vergely C, Simeoni U (2019) Calorie restriction in adulthood reduces hepatic disorders induced by transient postnatal overfeeding in mice

it goes where it's needed